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International Journal of Preclinical and Clinical Research

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Prospective Study of Custom-made Cemented Antibiotic Nail for the Treatment of Infected Non-union Tibia Fracture
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International Journal of Preclinical and Clinical Research

DOI: 10.51131/IJPCCR/v4i3.23.18

Year: 2023, Volume: 4, Issue: 3, Pages: 46-52

Original Article

Prospective Study of Custom-made Cemented Antibiotic Nail for the Treatment of Infected Non-union Tibia Fracture

Abdirizak Moalin Hussein1, Sujith Shahul1*, Shani Rahim2

1Specialist Orthopaedic Surgeon, Rashid Hospital, Dubai
2Specialist General Surgeon, Khorfakkan Hospital, Sharjah

*Corresponding Author
Email: [email protected]

Received Date:20 November 2023, Accepted Date:05 December 2023, Published Date:10 December 2023

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background and Objectives: Infection in long bones continues to present a significant challenge because of the necessity for multiple surgeries, extended treatment periods, and an unpredictable prognosis. An antibiotic cement-coated nail has shown promising potential due to the local antibiotic elution as well as the stabilization of bone defects. We conducted this study to compile our insights gained with the use of custom-made antibiotic cement nails for the management of infected as well as non-union tibia fractures. Methods: A prospective study was conducted in Rome University Hospital, Italy by enrolling 52 patients who were diagnosed with infected nonunion of the tibia and were treated with custom-made antibiotic-cement-coated nails. A custom-designed cement-coated nail was used for surgical procedures by combining PMMA bone cement, gentamycin PMMA, vancomycin, and sterile mineral oil. The evaluation of functional outcomes was performed in relation to the treatment of infection and the healing of bones. Results: After a period of 4 to 6 weeks, it was observed that all infection markers had returned to normal levels and only 7 patients required flap closure and bone graft. A majority of the patients (98%) showed signs of bone healing on x-ray, and there were no indications of infection based on the negative results of infection markers. This positive outcome was observed throughout an average follow-up period of 18 months. Conclusion: We found that using a cemented nail impregnated with antibiotics is an effective approach for managing postoperative infections and achieving successful reunion of bone.

Keywords: Infection, Non-Union Tibia, Impregnated Antibiotics, Bone Cement

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Copyright

© 2023 Hussein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Basaveshwara Medical College & Hospital, Chitradurga, Karnataka

  • 03 January 2024

Year: 2023, Volume: 4, Issue: 3


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