A Cross-Sectional Study of Blood Glucose Levels in Neonatal Sepsis and its Outcome in a Tertiary Care Hospital, Davangere

Mallisetty Narasinga Raj; Gayathri H Aradhya; Chaitali Raghoji

doi:10.51131/IJPCCR/v3i2.22_32

Article

A Cross-Sectional Study of Blood Glucose Levels in Neonatal Sepsis and its Outcome in a Tertiary Care Hospital, Davangere

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International Journal of Preclinical and Clinical Research

DOI: 10.51131/IJPCCR/v3i2.22_32

Year: 2022, Volume: 3, Issue: 2, Pages: 49-55

Original Article

A Cross-Sectional Study of Blood Glucose Levels in Neonatal Sepsis and its Outcome in a Tertiary Care Hospital, Davangere

Mallisetty Narasinga Raj ^{✉ 1} , Gayathri H Aradhya ² , Chaitali Raghoji ³

1 Senior resident, Department of Pediatrics, JJM Medical College, Davangere, Karnataka, India

2 Professor, Department of Pediatrics, JJM Medical College, Davangere, Karnataka, India

3 Assistant Professor, Department of Pediatrics, JJM Medical College, Davangere, Karnataka, India

Corresponding author ✉ [email protected]

Received Date:09 June 2022, Accepted Date:21 June 2022, Published Date:05 July 2022

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Sepsis is an important cause of morbidity and mortality among neonates. Neonatal sepsis can alter the glucose level, and both hypoglycaemia and hyperglycaemia may occur. Hence the present study aimed to study the clinical profile of patients with neonatal sepsis and to correlate the blood sugar levels with different outcomes in neonatal sepsis patients. A cross-sectional study was conducted at Bapuji Child Health Institute and Research Institute attached to J.J.M. Medical College, Davangere. A total of 90 neonates under the age of 28 days old admitted to NICU with probable and culture-proven neonatal sepsis were included in the study. Glucose levels, complete blood count, CRP levels, septic screening, lumbar puncture, neurosonogram, urine culture, blood culture and sensitivity were analysed. Results revealed that GRBS scores were < 40 for 24 subjects, 41 to 100 for 39 subjects, 101 to 200 for 22 subjects and > 200 for 5 subjects. There were 57(63.3%) males and 33(36.7%) females in the clinically diagnosed cases of septicemia. Clinical presentation in sepsis showed that 82(91.1%) subjects were not feeding well, 19(21.1%) had convulsions, 51(56.7%) had fast breathing, 39(43.3%) had Severe chest indrawing, 25(27.8%) had a temperature, 43(47.8%) had a fever and 88(97.8%) had Decreased activity of admission. In Conclusion, alteration of glycaemic status occurred in septic newborns, and mortality was higher among septic newborns with altered glycaemic status.

Keywords: Neonatal sepsis, GRBS, Hypoglycaemia, Hyperglycaemia, Mortality

References

Lander T. Neonatal and perinatal mortality: country, regional and global estimates. World Health Organization. 2006.
Gerdes JS. Diagnosis and management of bacterial infections in the neonate. Pediatric Clinics of North America. 2004;51(4):939–959. Available from: https://doi.org/10.1016/j.pcl.2004.03.009
Tallur SS, Kasturi AV, Nadgir SD, Krishna BVS. Clinico-bacteriological study of neonatal septicemia in Hubli. The Indian Journal of Pediatrics. 2000;67(3):169–174. Available from: https://doi.org/10.1007/bf02723654
Islam MZ, Aklima J, Yesmin F, Islam MS, Chakma K, Alauddin M, et al. Evaluation of hypoglycemic status and causative factors in neonatal sepsis. International Journal of Contemporary Pediatrics. 2017;4(6):1927. Available from: https://dx.doi.org/10.18203/2349-3291.ijcp20174120
Hyde TB, Hilger TM, Reingold A, Farley MM, O’brien KL, Schuchat A. Active Bacterial Core surveillance (ABCs) of the Emerging Infections Program Network. Trends in incidence and antimicrobial resistance of early-onset sepsis: population-based surveillance in San Francisco and Atlanta. Pediatrics. 2002;110(4):690–695. Available from: https://doi.org/10.1542/peds.110.4.690
Heath PT, Yusoff NN, Baker CJ. Neonatal meningitis. Arch Dis Child Fetal Neonatal Ed. 2003;88:173–181. Available from: https://doi.org/10.1136/fn.88.3.f173
Shaw CK, Shaw P, Thapalial A. Neonatal sepsis bacterial isolates and antibiotic susceptibility patterns at a NICU in a tertiary care hospital in western Nepal: a retrospective analysis. Kathmandu University medical journal (KUMJ). 2007;5(2):153–160. Available from: https://pubmed.ncbi.nlm.nih.gov/18604011/
Anwer SK, Mustafa S, Pariyani S, Ashraf S, Taufiq KM. Neonatal sepsis: an etiological study. Journal of Pakistan Medical Association. 2000;50(3):91–94. Available from: https://pubmed.ncbi.nlm.nih.gov/10795469/
Joshi SG, Ghole VS, Niphadkar KB. Neonatal gram-negative bacteremia. The Indian Journal of Pediatrics. 2000;67(1):27–32.
Edmond K, Zaidi A. New Approaches to Preventing, Diagnosing, and Treating Neonatal Sepsis. PLoS Medicine. 2010;7(3):e1000213. Available from: https://doi.org/10.1371%2Fjournal.pmed.1000213
Reshad M, Mundol T, K. MH, Prabhu AS. Study of the immediate clinical outcome of neonatal sepsis in the neonatal I.C.U. of a tertiary care hospital. International Journal of Contemporary Pediatrics. 2017;4(4):1401. Available from: http://dx.doi.org/10.18203/2349-3291.ijcp20172674
Jain A, Aggarwal R, Jeevasanker M, Agarwal R, Deorari AK, Paul VK. Hypoglycemia in the newborn. The Indian Journal of Pediatrics. 2008;75(1):63–67.
Najati N, Saboktakin L. Prevalence and Underlying Etiologies of Neonatal Hypoglycemia. Pakistan Journal of Biological Sciences. 2010;13(15):753–756. Available from: https://doi.org/10.3923/pjbs.2010.753.756
Ahmad S, Khalid R. https://doi.org/10.3923/pjbs.2010.753.756. J coll physicians Surg Pak. 2012;22(01):15–23. Available from: https://dx.doi.org/10.3923/pjbs.2010.753.756
Wilker RE. Hypoglycemia and Hyperglycemia. In: CJ, EE, SA., eds. Manual of Neonatal Care. (pp. 540-589) Lippincott Williams and Wilkins. 2008.
Begum S, Baki MA, Kundu GK, Islam I, Kumar M, Haque A. Bacteriological Profile of Neonatal Sepsis in a Tertiary Hospital in Bangladesh. Journal of Bangladesh College of Physicians and Surgeons. 2012;30(2):66–70. Available from: https://doi.org/10.3329/jbcps.v30i2.11406
Gupta BK, Gupta BK, Shrivastava AK, Chetri P. Glycemic status and its effect in Neonatal Sepsis - A prospective study in a Tertiary Care Hospital in Nepal. Journal of Advanced Pediatrics and Child Health. 2019;2(1):015–019. Available from: https://doi.org/10.29328/journal.japch.1001006
Ellahony DM, El-Mekkawy MS, Issa AEHRA. Prevalence of glucose level abnormalities in neonatal sepsis and its association with mortality. Menoufia Medical Journal. 2020;33(1):127. Available from: https://doi.org/10.4103/mmj.mmj_216_18
Jajoo M, Kapoor K, Garg LK, Manchanda V, Mittal SK. To study the incidence and risk factors of early onset neonatal sepsis in an out born neonatal intensive care unit of India. Journal of Clinical Neonatology. 2015;4(2):91–95. Available from: https://doi.org/10.4103/2249-4847.154106
Islam MS, Mia MAH, Akhter KR, Haque M, Malik MA. Glycemic Status and its Effect in Neonatal Sepsis in a Tertiary Care Hospital. Bangladesh Journal of Child Health. 2016;40(1):21–25.
Tripathi S, Kumar M, Kumar S, Ratan R. Profile of Neonates with Early Onset Neonatal Sepsis in A Level Three Neonatal Intensive Care Unit of Developing Country. Journal of Dental and Medical Science. 2017;16(8):15–18.

Copyright

© 2022 Raj et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Basaveshwara Medical College & Hospital, Chitradurga, Karnataka.