• E-ISSN 2583-0104
  • Follow us

International Journal of Preclinical and Clinical Research

Article

Serum uric acid measurement and its correlation with urinary albumin-creatinine ratio in type-2 Diabetic subjects
  • VIEWS 2478
  • PDF 638

International Journal of Preclinical and Clinical Research

DOI: 10.51131/IJPCCR/v2i1.5

Year: 2021, Volume: 2, Issue: 1, Pages: 5-7

Original Article

Serum uric acid measurement and its correlation with urinary albumin-creatinine ratio in type-2 Diabetic subjects

T V Aswathi1, Vickram2*, D Divya3

1 Postgraduate, Kannur University, Palayad, Kerala, India
2 Professor, Department of Biochemistry, Basaveshwara Medical College and Hospital, Chitradurga, 577502, Karnataka, India
3 Associate Professor, Department of Biochemistry, Basaveshwara Medical College and Hospital, Chitradurga, 577502, Karnataka, India

*Corresponding author
Email: [email protected]

Received Date:10 February 2021, Accepted Date:01 April 2021, Published Date:05 April 2021

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Increased serum uric acid (SUA) is known to play a critical role in the development of type-2 diabetes mellitus (T2DM) as well as in progression of its complications. Hyperuricemia is an independent risk factor for kidney dysfunction in patients with diabetes. The appearance of albuminuria is the first sign of kidney damage and the mechanisms of hyperuricemia-induced renal injury mainly include oxidative stress, endothelial dysfunction, renal fibrosis, and inflammation. To determine the possible association of SUA with urinary albumin-creatinine ratio (ACR) in type-2 diabetic subjects, data with lab investigations of SUA and urinary ACR of 95 confirmed and known cases of T2DM were collected from the laboratory medicine department, DMWIMS Hospital, Wayanad Kerala. Based on the urinary albumin excretion values, diabetic subjects were divided into three groups (Normoalbuminuric, microalbuminuric & macroalbuminuric groups). A significant increase in mean ACR from group-1-->group-2-->group- 3 was observed which is proportional to an increase in mean SUA levels suggesting that increase in SUA may be responsible for increased urinary albumin excretion. This study shows a positive correlation between SUA and ACR.

Keywords: Serum uric acid; diabetes mellitus; hyperuricemia; kidney damage; T2DM; albuminuria; urinary albumin-creatinine ratio; diabetic nephropathy

References

  1. Bonakdaran S, Hami M, Shakeri MT. Hyperuricemia and albuminuria in patients with type 2 diabetes mellitus. Iran J Kidney Dis. 2011;5(1):21–25.
  2. Bobulescu IA, Moe OW. Renal Transport of Uric Acid: Evolving Concepts and Uncertainties. Advances in Chronic Kidney Disease. 2012;19:358 371. doi: 10.1053/j.ackd.2012.07.009
  3. Su HY, Yang C, Liang D, Liu HF. Research Advances in the Mechanisms of Hyperuricemia-Induced Renal Injury. Biomed Res Int. 2020;2020:5817348.
  4. Jin M, Yang F, Yang I, Yin Y, Luo JJ, Wang H, et al. Uric acid, hyperuricemia and vascular diseases. Front Biosci. 2012;17:656–69.
  5. Bhole V, Choi JWJ, Kim SW, Vera Md, Choi H. Serum Uric Acid Levels and the Risk of Type 2 Diabetes: A Prospective Study. The American Journal of Medicine. 2010;123(10):957–961. doi: 10.1016/j.amjmed.2010.03.027
  6. Xiong Q, Liu J, Xu Y. Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications. Int J Endocrinol. 2019;p. 9691345.
  7. Kodama S, Saito K, Yachi Y, Asumi M, Sugawara A, Totsuka K, et al. Association Between Serum Uric Acid and Development of Type 2 Diabetes. Diabetes Care. 2009;32:1737–1742. doi: 10.2337/dc09-0288
  8. Fukui M, Tanaka M, Shiraishi E, I H, H H, M A, et al. Serum uric acid is associated with microalbuminuria and subclinical atherosclerosis in men with type 2 diabetes mellitus. Serum uric acid is associated with microalbuminuria and subclinical atherosclerosis in men with type 2 diabetes mellitus. Metab. 2008;57(5):625–634. doi: 10.1016/j.metabol.2007.12.005
  10. Bo S, Cavallo-Perin P, Gentile L, Repetti E, Pagano G. Hypouricemia and hyperuricemia in type 2 diabetes: two different phenotypes. European Journal of Clinical Investigation. 2001;31(4):318–321. doi: 10.1046/j.1365-2362.2001.00812.x
  11. Cosmo SD, Viazzi F, Pacilli A, Giorda C, Ceriello A, Gentile S, et al. AMD-Annals Study Group. Serum Uric Acid and Risk of CKD in Type 2 Diabetes. Clin J Am Soc Nephrol. 2015;10(11):1921–1930.
  12. Tsai CW, Lin SY, Kuo CC, Huang CC. Serum Uric Acid and Progression of Kidney Disease: A Longitudinal Analysis and Mini-Review. PLoS One. 2017;12(1):e170393.
  13. Behradmanesh S, Horestani MK, Baradaran A, Nasri H. Association of serum uric acid with proteinuria in type 2 diabetic patients. J Res Med Sci. 2013;18(1):44–50.
  14. Zatz R, Meyer TW, Rennke HG, Brenner BM. Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy. Proceedings of the National Academy of Sciences. 1985;82(17):5963–5967. doi: 10.1073/pnas.82.17.5963
  15. Latif H, Iqbal A, Rathore R, Butt NF. Correlation between Serum Uric Acid Level and Microalbuminuria in Type-2 Diabetic Nephropathy. Pakistan Journal of Medical Sciences. 2017;33(6):1371–1375. doi: 10.12669/pjms.336.13224
  16. Siu YP, Leung KT, Tong MKH, Kwan TH. Use of Allopurinol in Slowing the Progression of Renal Disease Through Its Ability to Lower Serum Uric Acid Level. American Journal of Kidney Diseases. 2006;47(1):51–59. doi: 10.1053/j.ajkd.2005.10.006
  17. Fu C, DW, Wang J, Yang W, Tseng C. Association of C-reactive protein and hyperuricemia with diabetic nephropathy in Chinese type 2 diabetic patients. Acta Diabetol. 2009 ;45(2):127–134. doi: 10.1007/s00592-008-0069-0

Copyright

© 2021 Aswathi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Basaveshwara Medical College & Hospital, Chitradurga, Karnataka

  • 05 April 2021

Year: 2021, Volume: 2, Issue: 1


More articles

DON'T MISS OUT!

Subscribe now for latest articles and news.