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International Journal of Preclinical and Clinical Research

Article

Serum uric acid measurement and its correlation with urinary albumin-creatinine ratio in type-2 Diabetic subjects
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International Journal of Preclinical and Clinical Research

DOI: 10.51131/IJPCCR/v2i1.5

Year: 2021, Volume: 2, Issue: 1, Pages: 5-7

Original Article

Serum uric acid measurement and its correlation with urinary albumin-creatinine ratio in type-2 Diabetic subjects

T V Aswathi1, Vickram2*, D Divya3

1 Postgraduate, Kannur University, Palayad, Kerala, India
2 Professor, Department of Biochemistry, Basaveshwara Medical College and Hospital, Chitradurga, 577502, Karnataka, India
3 Associate Professor, Department of Biochemistry, Basaveshwara Medical College and Hospital, Chitradurga, 577502, Karnataka, India

*Corresponding author
Email: [email protected]

Received Date:10 February 2021, Accepted Date:01 April 2021, Published Date:05 April 2021

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Increased serum uric acid (SUA) is known to play a critical role in the development of type-2 diabetes mellitus (T2DM) as well as in progression of its complications. Hyperuricemia is an independent risk factor for kidney dysfunction in patients with diabetes. The appearance of albuminuria is the first sign of kidney damage and the mechanisms of hyperuricemia-induced renal injury mainly include oxidative stress, endothelial dysfunction, renal fibrosis, and inflammation. To determine the possible association of SUA with urinary albumin-creatinine ratio (ACR) in type-2 diabetic subjects, data with lab investigations of SUA and urinary ACR of 95 confirmed and known cases of T2DM were collected from the laboratory medicine department, DMWIMS Hospital, Wayanad Kerala. Based on the urinary albumin excretion values, diabetic subjects were divided into three groups (Normoalbuminuric, microalbuminuric & macroalbuminuric groups). A significant increase in mean ACR from group-1-->group-2-->group- 3 was observed which is proportional to an increase in mean SUA levels suggesting that increase in SUA may be responsible for increased urinary albumin excretion. This study shows a positive correlation between SUA and ACR.

Keywords: Serum uric acid; diabetes mellitus; hyperuricemia; kidney damage; T2DM; albuminuria; urinary albumin-creatinine ratio; diabetic nephropathy

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Copyright

© 2021 Aswathi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Basaveshwara Medical College & Hospital, Chitradurga, Karnataka

  • 05 April 2021

Year: 2021, Volume: 2, Issue: 1


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