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International Journal of Preclinical and Clinical Research

Article

Detection of SARS-CoV-2 IgG Antibodies in Individuals Following Infection and Vaccination
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International Journal of Preclinical and Clinical Research

DOI: 10.51131/IJPCCR/v4i2.23.10

Year: 2023, Volume: 4, Issue: 2, Pages: 28-31

Original Article

Detection of SARS-CoV-2 IgG Antibodies in Individuals Following Infection and Vaccination

Manoj Vedpathak​ ✉ 1 , Deepak Shinde 1 , Sonal Agarwal 2 , Nasira Shaikh 3 , Prathamesh Bagewadi 4

1 Assistant Professor, Department of Microbiology, Dr. V.M. Government Medical College, Solapur, 413003, India
2 Research Scientist (Medical), Virus Research & Diagnostic Laboratory, Department of Microbiology, Dr, V.M. Government Medical College, Solapur, 413003, India
3 Associate Professor and Head, Department of Microbiology, Dr, V.M. Government Medical College, Solapur, 413003, India
4 Research Scientist (Non-medical), Virus Research & Diagnostic Laboratory, Department of Microbiology, Dr, V.M. Government Medical College, Solapur, 413003, India

Corresponding author ✉:  [email protected]

Received Date:24 May 2023, Accepted Date:01 August 2023, Published Date:14 August 2023

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

To contain the SARS-CoV-2 infection a number of measures including vaccination had taken to reduce virus transmission and mortality. Protection from a viral infection is mainly achieved by virus-neutralizing antibodies which are produced after infection or vaccination. But to what degree these can induce the production of neutralizing antibodies is poorly understood. To determine the development of SARS-CoV-2 IgG antibody production against spike protein after infection and vaccination. A prospective study was conducted from July 2021 to December 2021 at tertiary care hospital, Solapur. Based on the evidence of previous SARS-CoV-2 infection and status of vaccination, a total of 150 participants above 18 years of age were enrolled. A blood sample was collected for the serum to perform an Enzyme-linked immunosorbent assay (ELISA) using the ErbaLisa COVID-19 IgG kit. Chi-square test for goodness of fit was used to analyze the data. In this study, we have assessed the development of protective immunity and it was found that 89.33% (134/150) of participants had a detectable level of SARS-COV-2 IgG antibodies. Also, in the present study the development of antibodies following infection, after a first and second dose of vaccination is compared, and observed that SARS-COV-2 IgG antibodies were detected in 88% of participants following infection, in 84% of participants after the first dose, and in 96% after the second dose. Effective vaccination is an essential solution to decrease - the severity, transmissibility and the emergence of new variants.

Keywords: Covid antibody, Covid-19 immune response, SARS-CoV-2 IgG, vaccination

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Copyright

© 2023 Vedpathak et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Basaveshwara Medical College & Hospital, Chitradurga, Karnataka

  • 14 August 2023

Year: 2023, Volume: 4, Issue: 2


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