A study on serum uric acid levels and insulin resistance in type-2 diabetic subjects

N Thweja; D Divya; Vickram

doi:10.51131/IJPCCR/v2i2.16

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International Journal of Preclinical and Clinical Research

DOI: 10.51131/IJPCCR/v2i2.16

Year: 2021, Volume: 2, Issue: 2, Pages: 38-41

Original Article

A study on serum uric acid levels and insulin resistance in type-2 diabetic subjects

N Thweja ¹, D Divya ^2,*, Vickram ³

1 Post graduate, Kannur University, Kerala

2 Associate Professor, Department of Biochemistry, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, 577502, India

3 Professor, Department of Biochemistry, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, 577502, India

Corresponding author email: [email protected]

Received Date:07 July 2021, Accepted Date:12 July 2021, Published Date:19 July 2021

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Insulin resistance (IR) is the principle etiological factor for development and progression of type-2 diabetes mellitus (T2DM) and decreased insulin function. Independently, increased serum uric acid (SUA) is known to play a critical role in the development of T2DM as well as in progression of its complications. To assess the correlation between SUA levels and IR in diabetic patients, data with lab investigations of HbA1c, fasting levels of serum glucose, UA, TAG, HDL-C of confirmed and known cases of T2DM were collected from the Hospital Biochemistry Laboratory, DMWIMS Hospital, Wayanad, Kerala. Fasting ratio of TAG to HDL-C was used as an index for IR. A significant increase in fasting serum glucose, SUA, HBA1C, TAG, TAG/HDL-C ratio (IR) and a significant decrease in HDL-C were observed in data of cases when compared with the data of normal healthy subjects. This study shows a positive correlation between SUA levels and IR in known cases of T2DM.

Keywords

type2 diabetes mellitus, serum uric acid, insulin resistance

References

Kodama S, Saito K, Yachi Y, Asumi M, Sugawara A, Totsuka K, et al. Association Between Serum Uric Acid and Development of Type 2 Diabetes. Diabetes Care. 2009;32(9):1737–1742. Available from: https://dx.doi.org/10.2337/dc09-0288
Čaušević A, Semiz S, Macić-Džanković A, Cico B, Dujić T, Malenica M, et al. Relevance of uric Acid in progression of type 2 diabetes mellitus. Bosn J Basic Med Sci. 2010;10(1):54–59. Available from: https://doi.org/10.17305/bjbms.2010.2736
Neeley WE. Simple Automated Determination of Serum or Plasma Glucose by a Hexokinase/Glucose-6-Phosphate Dehydrogenase Method. Clinical Chemistry. 1972;18(6):509–515. Available from: https://dx.doi.org/10.1093/clinchem/18.6.509
Bondar RJ, Mead DC. Evaluation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides in the hexokinase method for determining glucose in serum. Clin Chem. 1974;20(5):586–590.
Mayer TK, Freedman ZR. Protein glycosylation in diabetes mellitus: a review of laboratory measurements and of their clinical utility. Clin Chim Acta. 1983;127(2):147–184. Available from: 10.1016/s0009-8981(83)80002-3
Siedel J, Schmuck R, Staepels J, Town MH. Long term stable, liquid ready to use monoreagent for the enzymatic assay of serum or plasma triglycerides (GPO-PAP method). AACC Meeting Abstract 34. Clin Chem. 1993;39(1127).
Sugiuchi H, Uji Y, Okabe H. Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and sulfated alpha-cyclodextrin. Clin Chem. 1995;41(5):717–723.
Matsuzaki Y, Kawaguchi E, Morita Y, Mashige F, Ohisa S, Nakahara K. Evaluation of two kinds of reagents for direct determination of HDL-cholesterol. J Anal Bio-Sc. 1996;19:419–446.
Kageyama N. A direct colorimetric determination of uric acid in serum and urine with uricase-catalase system. Clinica Chimica Acta. 1971;31(2):421–426. Available from: https://dx.doi.org/10.1016/0009-8981(71)90413-x
Digiorgio J, Henry RJ. Clinical chemistry: Principles and Technics. (Vol. 84, p. 217) Harper and Row. 1972.
Li C, Ford ES, Meng YX, Mokdad AH, Reaven GM. Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity? Cardiovascular Diabetology. 2008;7(1):4. Available from: https://dx.doi.org/10.1186/1475-2840-7-4
Snehalatha C, Satyavani K, Sivasankari S, Vijay V, Ramachandran A. Serum triglycerides as a marker of insulin resistance in non-diabetic urban Indians. Diabetes Res Clin Pract. 2005;69(2):205–206. Available from: 10.1016/j.diabres.2005.03.021
Bovet P, Faeh D, Gabriel A, Tappy L. The Prediction of Insulin Resistance With Serum Triglyceride and High-Density Lipoprotein Cholesterol Levels in an East African Population. Archives of Internal Medicine. 2006;166(11):1236–1237. Available from: https://dx.doi.org/10.1001/archinte.166.11.1236-b
Wu YT, He H, Wang X, Zhang M, An ZM, Huang HJ. Serum Uric Acid and Islet β-cell Function in Patients with Pre-diabetes and Type 2 Diabetes Mellitus. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018;49(1):69–73. Available from: https://pubmed.ncbi.nlm.nih.gov/29737093/
Zoppini G, Targher G, Chonchol M, Ortalda V, Abaterusso C, Pichiri I, et al. Serum Uric Acid Levels and Incident Chronic Kidney Disease in Patients With Type 2 Diabetes and Preserved Kidney Function. Diabetes Care. 2012;35(1):99–104. Available from: https://dx.doi.org/10.2337/dc11-1346
Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131(1):7–13. Available from: 10.7326/0003-4819-131-1-199907060-00003
Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, et al. Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism. Hypertension. 2001;38(5):1101–1106. doi: 10.1161/hy1101.092839
Yoo TW, Sung KC, Shin HS. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J. 2005;69(8):928–933. Available from: 10.1253/circj.69.928
Vuorinen-Markkola H, Yki-Järvinen H. Hyperuricemia and insulin resistance. J Clin Endocrinol Metab. 1994;78(1):25–29. Available from: 10.1210/jcem.78.1.8288709
Cigolini M, Targher G, Tonoli M, Manara F, Muggeo M, Sandre D, et al. Hyperuricaemia: relationships to body fat distribution and other components of the insulin resistance syndrome in 38-year-old healthy men and women. Int J Obes Relat Metab Disord. 1995;19(2):92–96.
Yi-LiXu, Kuan-FengXu, Jian-LingBai, YunLiu, Rong-BinYu, Chun-LanLiu, et al. Elevation of serum uric acid and incidence of type 2 diabetes: A systematic review and meta-analysis. Chronic Dis Transl Med. 2016;2(2):81–91. Available from: https://doi.org/10.1016/j.cdtm.2016.09.003
Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16(12):3553–3562. Available from: 10.1681/ASN.2005050572
King C, Lanaspa MA, Jensen T, Tolan DR, Sánchez-Lozada LG, Johnson RJ. Uric Acid as a Cause of the Metabolic Syndrome. Contrib Nephrol. 2018;192:88–102. Available from: 10.1159/000484283

Copyright

© 2021 Thweja et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Basaveshwara Medical College & Hospital, Chitradurga, Karnataka.