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  <front>
    <journal-meta id="journal-meta-bc63e75bd5324da48c1c39c85223bd02">
      <journal-id journal-id-type="nlm-ta">Sciresol</journal-id>
      <journal-id journal-id-type="publisher-id">Sciresol</journal-id>
      <journal-id journal-id-type="journal_submission_guidelines">https://ijpccr.com/#</journal-id>
      <journal-title-group>
        <journal-title>International Journal of Preclinical &amp; Clinical Research</journal-title>
      </journal-title-group>
      <issn publication-format="electronic">2583-0104</issn>
      <issn publication-format="print"/>
    </journal-meta>
    <article-meta id="article-meta-d5b2f8eb5a72490da3f5c47ea242d64e">
      <article-id pub-id-type="doi">10.51131/IJPCCR/v4i1.23.8</article-id>
      <article-categories>
        <subj-group>
          <subject>Case Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title id="article-title-d7526d55815b4801b30e35d7cf2c5454">
          <bold id="strong-cb5ae27bcb1a44e1a7d459f0978727f4">Giant Cell Tumour </bold>
          <bold id="strong-13df03dea49b4b1abc2c34428bb9dd6b">o</bold>
          <bold id="strong-336f245a047245a7bcb47e7cd63e24ef">f Medial Condyle </bold>
          <bold id="strong-68aedf66f0f3466eb8d1904eee7c5725">of Left Tibia</bold>
        </article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name id="name-e54baef645be493495beeacb0582f340">
            <surname>Kuri</surname>
            <given-names>Praveen Y</given-names>
          </name>
          <email>kuripraveen@gmail.com</email>
          <xref id="xref-5c25b2f57b8d4e288d0c9f76f7c1e19f" rid="aff-90af769a48064780a5bd534835a20931" ref-type="aff">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name id="name-a9f0902ae3a64baea86269fa653f5ebd">
            <surname>Channareddy</surname>
            <given-names>H</given-names>
          </name>
          <xref id="xref-120ef7435dbf45b99bb279ba4254dd0a" rid="aff-532990d5f3674fdd9c09437d6c645ad4" ref-type="aff">2</xref>
        </contrib>
        <aff id="aff-90af769a48064780a5bd534835a20931">
          <institution>Junior Resident, Department of Orthopaedics, Basaveshwara Medical College and Hospital</institution>
          <addr-line>Chitradurga, Karnataka</addr-line>
          <country country="IN">India</country>
        </aff>
        <aff id="aff-532990d5f3674fdd9c09437d6c645ad4">
          <institution>Professor, Department of Orthopaedics, Basaveshwara Medical College and Hospital</institution>
          <addr-line>Chitradurga, Karnataka</addr-line>
          <country country="IN">India</country>
        </aff>
      </contrib-group>
      <volume>4</volume>
      <issue>1</issue>
      <fpage>21</fpage>
      <permissions>
        <copyright-year>2023</copyright-year>
      </permissions>
      <kwd-group id="kwd-group-ff0a604316f04f73b839020636fe2319">
        <title>Keywords</title>
        <kwd/>
      </kwd-group>
      <funding-group>
        <funding-statement>None</funding-statement>
      </funding-group>
    </article-meta>
  </front>
  <body>
    <sec>
      <p id="p-3ba42a9113f4">﻿</p>
    </sec>
    <sec>
      <title id="title-9622606a4aff43cd83ce42505607afda">Introduction</title>
      <p id="paragraph-278c85b170974ab48cb1a957ab11a90d">Giant cell tumour of bone presents as a locally aggressive lesion with unpredictable behaviour. Recurrence of the tumour is very common</p>
      <sec>
        <title id="t-f927ead52233">
          <bold id="strong-9a25e4aac4574602a0c11a2a81cf3755">Case report</bold>
        </title>
        <p id="paragraph-807438b386d545589d5ff59c3fcfa940">A 21-year-old male patient, presented with c/o pain and swelling in the left knee since 5 months. O/E-Left Knee-swelling and tenderness present over the proximal tibia. ROM-Terminal movements are painful and restricted.</p>
      </sec>
      <sec>
        <title id="t-99c5d956d483">
          <bold id="strong-afa2cdf63b2d4f159f9b96ccddfca23d">X-Ray</bold>
          <bold id="strong-724031fd29004bcdae68a0103e22e3f0"> </bold>
          <bold id="strong-be6eaf0dd25a460bb659d8f081c8848c">Left knee with proximal leg - AP and Lateral</bold>
        </title>
        <list list-type="bullet">
          <list-item id="li-b93c510d8b34">
            <p>Osteolytic lesion seen in the medial condyle of tibia.</p>
          </list-item>
          <list-item id="li-bc3c499de019">
            <p>Eccentric in location.</p>
          </list-item>
          <list-item id="li-46fd2a639084">
            <p>Anterior cortex-Expanded and thinned out.﻿</p>
          </list-item>
        </list>
        <fig id="figure-9be7ce9a7f1a44d4b85f84012235fc2e" orientation="portrait" fig-type="graphic" position="anchor">
          <label>Figure 1 </label>
          <caption id="caption-28039981c4a14a0294291a1104836555">
            <title id="title-4c57412cacc340e2bc850442fcce3c10">
              <bold id="s-303c1143fbc3">X-Ray</bold>
              <bold id="s-b959d24474b5"> </bold>
              <bold id="s-7235b5196ca3">Left knee with proximal leg: AP and Lateral</bold>
            </title>
          </caption>
          <graphic id="graphic-fc49ac614f3b42c19f4cd1cbd5f3fe67" xlink:href="https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/b7444ce5-3541-404a-aac1-18e7d94845c6image1.png"/>
        </fig>
      </sec>
      <sec>
        <title id="t-41939fbe02d7">﻿<bold id="strong-4b2285c8074a4b33a26502fe59c298c9">MRI Left knee and leg</bold></title>
        <p id="paragraph-cb562047387a4f7690b11dcd3a4ecd6c">Feature suggestive of Aneurysmal bone cyst medial tibial condyle left side﻿</p>
        <fig id="figure-a6b966aa63624908a5db87365e0fc759" orientation="portrait" fig-type="graphic" position="anchor">
          <label>Figure 2 </label>
          <caption id="caption-77fe4e099ff4400ca800fedb774f86c0">
            <title id="title-e7fbc0062ec94bb1aa3e9c3a1f1c9341">
              <bold id="s-ae56c17a6a55">MRI Left knee and leg</bold>
            </title>
          </caption>
          <graphic id="graphic-5aa41964c10a4a528cf9e5d237016f82" xlink:href="https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/b7444ce5-3541-404a-aac1-18e7d94845c6image2.png"/>
        </fig>
        <p id="p-a4a5cbee3a4d">﻿</p>
      </sec>
      <sec>
        <title id="t-9f0f3e2101d0">
          <bold id="strong-da4c8fc7d7114544b240c24481fc5a05">FNAC</bold>
        </title>
        <p id="paragraph-6547dd53fa6443dca372e4827fae0e17">Diffuse hemorrhage along with acute and chronic inflammatory cells.</p>
      </sec>
      <sec>
        <title id="t-19177ced5e2a">
          <bold id="strong-92730026f0b040fc99c34825d4ef8364">Open biopsy</bold>
        </title>
        <p id="paragraph-cfb4137b8a9249f885be00d9294f8839">Feature suggestive of Giant cell tumour (GCT)of bone.</p>
        <p id="paragraph-eb8f93bc5c67498683b79ced4d8865ee">No evidence of malignancy</p>
      </sec>
      <sec>
        <title id="t-31404ec09069">
          <bold id="strong-285d38b6f43a4ca9a522db6dd4a5948e">Diagnosis</bold>
        </title>
        <p id="paragraph-d364a4cf98f9477ba785f30209507b9b">Based on clinical, radiological and open biopsy, giant cell tumour of medial condyle of left tibia was diagnosed.</p>
      </sec>
      <sec>
        <title id="t-d04a065ebe43">
          <bold id="strong-099d617913a34998a30d5ef3e6f88b3b">Treatment</bold>
        </title>
        <list list-type="bullet">
          <list-item id="li-15e2179fa9f7">
            <p>Curettage+High speed burr+Electrocautery+Hydrogen peroxide [Extended curettage and Adjunct therapy]</p>
          </list-item>
          <list-item id="li-71467454830e">
            <p>Cavity was filled with Subchondral cortico-cancellous autograft + Gel foam+ PMMA bone cement[Sandwich technique]</p>
          </list-item>
          <list-item id="li-b01ae9214eb2">
            <p>Bone was stabilized with 6.5 mm cancellous screw and 4.5 mm cortical screw.</p>
          </list-item>
          <list-item id="li-09bb6d8fc8a4">
            <p>Inj Zolendronic acid 5mg IV once in a month was given post-operatively, for 4 months</p>
          </list-item>
        </list>
      </sec>
      <sec>
        <title id="t-e2d7bf2a0bc0">
          <bold id="strong-66ed91ab11f34db69e92b77d885096ad">Post operative X-ray</bold>
        </title>
        <fig id="figure-7c35e7ef8886470e90120f1b90fa0440" orientation="portrait" fig-type="graphic" position="anchor">
          <label>Figure 3 </label>
          <caption id="caption-d429c863a4db450691ea3eba80ef3aea">
            <title id="title-94beacffa8164b0e9a9b20debae55235">
              <bold id="s-26ed880e9c77">Post operative X-ray</bold>
            </title>
          </caption>
          <graphic id="graphic-e2373bb796d5482b8f0c437f4331c2db" xlink:href="https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/b7444ce5-3541-404a-aac1-18e7d94845c6image3.png"/>
        </fig>
        <p id="paragraph-33aa9dab1cad4e3bae1558c64561e37b"/>
        <fig id="figure-81dbd63c2e2d4ac9af95b079a85e73fa" orientation="portrait" fig-type="graphic" position="anchor">
          <label>Figure 4 </label>
          <caption id="caption-821b9cedba4a49189d2e2c710c114c24">
            <title id="title-9459121cb5d94e8fba489b0d22286238">
              <bold id="strong-9437da94dcab415b8d6ea8ccef8e143e">Follow up X-ray: After 3 months and 3 years</bold>
            </title>
          </caption>
          <graphic id="graphic-9d988718f90d4a22a26208644c7d40e9" xlink:href="https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/b7444ce5-3541-404a-aac1-18e7d94845c6image4.png"/>
        </fig>
      </sec>
    </sec>
    <sec>
      <title id="title-8205dd50841743beab9f0b7cbe156c84">Conclusion</title>
      <list list-type="bullet">
        <list-item id="li-a51186ccf8f4">
          <p>GCT is a locally aggressive tumour treated successfully with extended curettage, bonegraft and cementation (Sandwich technique)</p>
        </list-item>
        <list-item id="li-33296beaa273">
          <p>Inj Zolendronic acid was given to prevent the recurrence.</p>
        </list-item>
        <list-item id="li-c018ab6d62e0">
          <p>No recurrence of the tumour is seen after 3 years of follow up.</p>
        </list-item>
      </list>
      <p id="paragraph-9df95eaf43ba402fa2ff2c8650fcc1fd">Extended curettage and IV Zolendronic acid are important in prevention of recurrence of GCT</p>
    </sec>
  </body>
  <back/>
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