Comparative evaluation of efficacy of ferrous ascorbate and ferrous calcium citrate prepared in multidrug delivery system on haemoglobin status in anaemic pregnant women

L J Kiran; B E Pradeep; M S Raghuprasada; V S Harish Kumar; A N Pradeep; K G Shivashankaramurthy

doi:10.51131/IJPCCR/v1i1.3

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International Journal of Preclinical and Clinical Research

DOI: 10.51131/IJPCCR/v1i1.3

Year: 2020, Volume: 1, Issue: 1, Pages: 7-11

Original Article

Comparative evaluation of efficacy of ferrous ascorbate and ferrous calcium citrate prepared in multidrug delivery system on haemoglobin status in anaemic pregnant women

L J Kiran¹, B E Pradeep², M S Raghuprasada³, V S Harish Kumar³, A N Pradeep⁴, K G Shivashankaramurthy^5*

¹ Professor and Head, Department of Pharmacology, S.S Institute of Medical Sciences and Research Centre, Davangere, Karnataka
² Tutor, Department of Pharmacology, S.S Institute of Medical Sciences and Research Centre, Davangere, Karnataka
³ Associate Professor, Department of Pharmacology, S.S Institute of Medical Sciences and Research Centre, Davangere, Karnataka
⁴ Assistant Professor, Department of Pharmacology, S.S Institute of Medical Sciences and Research Centre, Davangere, Karnataka
⁵ Professor, Department of Pharmacology, S.S Institute of Medical Sciences and Research Centre, Davangere, Karnataka

*Corresponding author
Email: [email protected]

Received Date:04 December 2020, Accepted Date:12 December 2020, Published Date:21 December 2020

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Iron deficiency anaemia (IDA), the most prevalent nutritional deficiency leading to mortality globally. Oral ferrous salts are effectively used to treat iron deficiency in pregnancy. For the present study, no direct comparison demonstrating the efficacy of ferrous ascorbate and ferrous calcium citrate was considered. An open-label, observational study was designed and conducted for two months. Subjects were randomly allocated to two groups (Group A and Group B). The medication followed in Group A was, ferrous calcium citrate with elemental iron 50 mg; In Group B ferrous ascorbate containing elemental iron 100 mg orally for two months at bedtime. Haemoglobin levels, other hematological parameters, weight changes, side effects, conjunctival colour and general wellbeing were assessed in every visit (i.e. 0, 30th and 60th day) for clinical efficacy assessment. There was an increase in the mean serum haemoglobin and ferritin levels (p<0.05). In Group A and Group B, the mean values of all the assessment parameters increased significantly (p<0.05) in follow-up visits (i.e. 1st month and 2nd month) when compared to baseline values. Out of 69 adverse drug events, 29 (42%) were reported from Group A and 40 (58%) from Group B. Ferrous calcium citrate showed considerable efficacy and safety profiles.

Keywords: Iron deficiency; anaemia; haemoglobin; ferrous calcium citrate; ferrous ascorbate

References

Diejomaoh FME, Abdulaziz A, Adekile AD. Anemia in pregnancy. International Journal of Gynecology & Obstetrics. 1999;65(3):299–301. Available from: https://dx.doi.org/10.1016/s0020-7292(99)00034-x
World Health Organization, Geneva The prevalence of anemia in women: a tabulation of available information.
Sarin AR. Severe anemia of pregnancy, recent experience. International Journal of Gynecology & Obstetrics. 1995;50:S45–S49. Available from: https://dx.doi.org/10.1016/0020-7292(95)02485-u
Rajamouli J, Ravinder A, Reddy SCK, Pambi S. Study on prevalence of anemia among pregnant women attending antenatal clinic at rural health training centre (RHTC) and chalmeda anand rao institute of medical sciences teaching hospital. International Journal of Contemporary Medical Research. 2016;3(8):2388–2391.
Letsky EA. The hematological system. (2). (pp. 39-82) Oxford, United Kingdom. Blackwell Scientific Publications. 1991.
Fenton V, Cavill I, Fisher J. Iron Stores in Pregnancy. British Journal of Haematology. 1977;37(1):145–149. Available from: https://dx.doi.org/10.1111/j.1365-2141.1977.tb08819.x
Galan P, Cherouvrier F, Zohoun I, Zohoun T, Chauliac M, Hercberg S. Iron absorption from typical West African meals containing contaminating Fe. British Journal of Nutrition. 1990;64(2):541–546. Available from: https://dx.doi.org/10.1079/bjn19900053
Viteri F. Iron supplementation for the control of iron deficiency anemia in population at risk. Nutr Rev. 1997;55:189–203.
Allen L. Pregnancy and iron deficiency: unresolved issues. Nutr Rev. 1997;55:91–101.
Sharma JB, Soni D, Murthy NS, Malhotra M. Effect of dietary habits on prevalence of anemia in pregnant women of Delhi. Journal of Obstetrics and Gynaecology Research. 2003;29(2):73–78. Available from: https://dx.doi.org/10.1046/j.1341-8076.2003.00079.x
Sharma JB. Medical complications in pregnancy. In: Sharma JB., ed. The obstretic protocol (1). (pp. 78-98) Delhi, India. Jaypee Brothers. 1998.
Sharma JB. Nutritional anemia during pregnancy in non-industrialised countries. In: Studd J., ed. Progress in obstretics and gynaecology. (pp. 103-125) Edinburg. Churchill Livingstone. 2003.
Mason J, Rivers J, Helwig C. Recent trends in malnutrition in developing regions: Vitamin A deficiency, anemia, iodine deficiency, and child underweight. Food and Nutrition Bulletin. 2005;26(1):57. Available from: https://dx.doi.org/10.1177/156482650502600107
Miyashita K, Tojo A, Kimura K. Iron Deficiency and Other Hypoproliferative Anemias. In: Longo F, Kasper H, Jameson L., eds. Harrison’s Principles of Internal Medicine (18th International). (pp. 586-593) McGraw Hill. 2011.
Tokars ML. Luitpoid Pharmaceuticals Comparison of safety and Efficacy of Intravenous Iron Versus Oral Iron in Chronic Renal Failure Subjects with Anemia. 2010. Available from: www.clinicaltrials.gov/ct2/show/NCT00236977
Asma S, Boga C, Ozdogu H. Safety, therapeutic effectiveness, and cost of parenteral iron therapy. International Journal of Hematology. 2009;90(1):24–27. Available from: https://dx.doi.org/10.1007/s12185-009-0352-z
Mircescu G, Gârneaţă L, Căpuşă C, Ursea N. Intravenous iron supplementation for the treatment of anaemia in pre-dialyzed chronic renal failure patients. Nephrology Dialysis Transplantation. 2006;21(1):120–124. Available from: https://dx.doi.org/10.1093/ndt/gfi087
Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. Hematopoietic system & treatment of anemia. In: Rang and Dales Pharmacology (7th International edition). (Vol. 2011, pp. 309-319) ELSEVIER Churchill Livingstone..
Halemani SS, Lakkol K, Acharya A. Comparison of efficacy of ferrous calcium citrate Vs ferrous ascorbate on Hb status in anaemic pregnant women. Int J Pharm Sci & Res. 2018;9(3):1242–1246.

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© 2020 Kiran et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published By Basaveshwara Medical College & Hospital, Chitradurga, Karnataka.